Gebruikersprofielen voor author:"Zeller Georg"

Georg Zeller

EMBL, Heidelberg
Geverifieerd e-mailadres voor embl.de
Geciteerd door 16837

Extensive impact of non-antibiotic drugs on human gut bacteria

L Maier, M Pruteanu, M Kuhn, G Zeller, A Telzerow… - Nature, 2018 - nature.com
A few commonly used non-antibiotic drugs have recently been associated with changes in
gut microbiome composition, but the extent of this phenomenon is unknown. Here, we
screened more than 1,000 marketed drugs against 40 representative gut bacterial strains …

Structure and function of the global ocean microbiome

S Sunagawa, LP Coelho, S Chaffron, JR Kultima… - …, 2015 - science.sciencemag.org
Microbes are dominant drivers of biogeochemical processes, yet drawing a global picture of
functional diversity, microbial community structure, and their ecological determinants
remains a grand challenge. We analyzed 7.2 terabases of metagenomic data from 243 Tara …

Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project

MB Gerstein, ZJ Lu, EL Van Nostrand, C Cheng… - …, 2010 - science.sciencemag.org
We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include
transcriptome profiling across a developmental time course, genome-wide identification of …

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

J Wirbel, PT Pyl, E Kartal, K Zych, A Kashani… - Nature medicine, 2019 - nature.com
Association studies have linked microbiome alterations with many human diseases.
However, they have not always reported consistent results, thereby necessitating cross-
study comparisons. Here, a meta-analysis of eight geographically and technically diverse …

Common sequence polymorphisms shaping genetic diversity in Arabidopsis thaliana

RM Clark, G Schweikert, C Toomajian… - …, 2007 - science.sciencemag.org
The genomes of individuals from the same species vary in sequence as a result of different
evolutionary processes. To examine the patterns of, and the forces shaping, sequence
variation in Arabidopsis thaliana, we performed high-density array resequencing of 20 …

Enterotypes in the landscape of gut microbial community composition

PI Costea, F Hildebrand, M Arumugam, F Bäckhed… - Nature …, 2018 - nature.com
Population stratification is a useful approach for a better understanding of complex
biological problems in human health and wellbeing. The proposal that such stratification
applies to the human gut microbiome, in the form of distinct community composition types …

Genomewide SNP variation reveals relationships among landraces and modern varieties of rice

KL McNally, KL Childs, R Bohnert… - Proceedings of the …, 2009 - National Acad Sciences
Rice, the primary source of dietary calories for half of humanity, is the first crop plant for
which a high-quality reference genome sequence from a single variety was produced. We
used resequencing microarrays to interrogate 100 Mb of the unique fraction of the reference …

Towards standards for human fecal sample processing in metagenomic studies

PI Costea, G Zeller, S Sunagawa, E Pelletier… - Nature …, 2017 - nature.com
Technical variation in metagenomic analysis must be minimized to confidently assess the
contributions of microbiota to human health. Here we tested 21 representative DNA
extraction protocols on the same fecal samples and quantified differences in observed …

Potential of fecal microbiota for early‐stage detection of colorectal cancer

G Zeller, J Tap, AY Voigt, S Sunagawa… - Molecular systems …, 2014 - embopress.org
Several bacterial species have been implicated in the development of colorectal carcinoma
(CRC), but CRC‐associated changes of fecal microbiota and their potential for cancer
screening remain to be explored. Here, we used metagenomic sequencing of fecal samples …

Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana

S Laubinger, T Sachsenberg, G Zeller… - Proceedings of the …, 2008 - National Acad Sciences
The processing of Arabidopsis thaliana microRNAs (miRNAs) from longer primary
transcripts (pri-miRNAs) requires the activity of several proteins, including DICER-LIKE1
(DCL1), the double-stranded RNA-binding protein HYPONASTIC LEAVES1 (HYL1), and the …