Abstract beta-Lapachone is a plant product that has been found to have many
pharmacological effects. To date, very little is known about its biochemical target. In this
study, we found that beta-lapachone inhibits the catalytic activity of topoisomerase I from calf …

BACKGROUND: There are two fundamental forms of cell death: apoptosis and necrosis.
Molecular studies of cell death thus far favor a model in which apoptosis and necrosis share
very few molecular regulators. It appears that apoptotic processes triggered by a variety of …

Beta-lapachone is a potent inhibitor of DNA repair in mammalian cells and activates
topoisomerase I. We show that beta-lapachone can prevent the oncogenic transformation of
CHEF/18A cells by ionizing radiation. Potentially lethal DNA damage repair (PLDR) occurs …

Naphthoquinones, such as beta-lapachone, 4-alkoxy-1, 2-naphthoquinones, and
tetrahydrofuran-1, 2-naphthoquinones, react rapidly with 2-mercaptoethanol in benzene to
give 1, 4-, 1, 2-, 1, 3-and 1, 6-Michael-type adducts that are formed by the addition of the …

BACKGROUND: Human multiple myeloma (MM) remains an incurable hematological
malignancy. We have reported that beta-lapachone, a pure compound derived from a plant,
can induce cell death in a variety of human carcinoma cells, including ovary, colon, lung …

synthesized in this series by using the naphthalenediones 3 as intermediates. Of these, the
dimethoxy derivative 3d has previously been synthesized* starting from ethyl
homoveratrate? For the preparation of the naphthoquinones 38-c, the methylindenes la-c …

BACKGROUND: Human colon cancers have a high frequency of p53 mutations, and cancer
cells expressing mutant p53 tend to be resistant to current chemo-and radiation therapy. It is
thus important to find therapeutic agents that can inhibit colon cancer cells with altered p53 …

Abstract beta-lapachone (beta-lap) is a lipophilic o-naphthoquinone isolated from the bark of
the lapacho tree. Initial observations proved its capability for inhibiting growth of Yoshida
tumor and Walker 256 carcinosarcoma. beta-Lap redox-cycling in the presence of …

In present study we studied the cytotoxic effects of beta-lapachone, a potent anticancer drug,
on the human hepatoma cell line (HepA2) under serum-free condition. Most cells died after
2 microM beta-lapachone addition at 48 hours. No apoptotic characteristics of DNA ladder …

NAD (P) H: quinone oxidoreductase (NQO1) is elevated in human pancreatic cancers. We
hypothesized that£]-lapachone, a novel 1, 2-naphthoquinone with potential antitumor activity
in cancer cells expressing elevated levels of NQO1, would induce cytotoxicity in pancreatic …