… βL-fed mice did not alter their food-intake or locomotor activity but did increase their energy
expenditure as measured by oxygen consumption and heat generation … (2012) Beta-Lapachone,
a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice …

… Res., 1999, 30(1), 73-83 [15] Woo, HJ; Park, KY; Rhu, CH Beta-lapachone, a quinone iso- lated
from Tabebuia avellanedae, induces apoptosis in HepG2 he- patoma cell line through induction
of Bax and activation of caspase. J. Med. Food, 2006, 9(2), 161-168 [16] Manna, SK …

… Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof,
and methods of using same. Download PDF Info … Emulsions of Beta-Lapachone in a
pharmaceutically acceptable fat emulsion vehicle are also provided …

… Page 2. TOXICOLOGICAL ASSESSMENT OF BETA-LAPACHONE 1277 … As observed in Tables
1 and 2, the beta-lap at the three doses (40, 80, and 160 mg/kg) administered on days 7–12 cage,
with a light/dark period of 12 h (6:00 am to 6:00 pm) and food and water ad libitum …

… J. Med. Food, 13, 481–488 (2010). 8) Ferreira SB, Salomao K, de Carvalho da Silva F, Pinto AV,
Kaiser CR, Pinto AC, Ferreira VF, de Castro SL. Synthesis and anti-Trypanosoma cruzi activity
of beta-lapachone analogues. Eur. J. Med. Chem., 46, 3071–3077 (2011) …

Page 1. Beta-lapachone prevents diet-induced obesity by increasing energy expenditure and …
Won Hee Choi1,2, Jiyun Ahn1,2, Chang Hwa Jung1.2, Young Jin Jang1, Tae Youl Ha1,2
1Research Group of Nutrition and Metabolic System, Korea Food Research Institute …

… In vitro dissolution studies were performed following Food and Drug Administration (FDA)
specifications for poor sol- uble drugs using a United States Pharmacopeia (USP) dis- solution
apparatus 2 (paddle) (Turu Grau DT-6, Barcelona, Spain) at 75 rpm and 37-C (±0.5-C).28 …

… b-lap, beta-lapachone … H, Yamashita S. Effect of administration site in the gastrointestinal tracton
bioavailability of poorly absorbed drugstaken after a meal … P, Knutson L, Ohgren C, Forssén S,
Lennernäs H, Abrahamsson B. Improved understanding of the effect of food on drug …

… In recent, a Food and Drug Administration (FDA)- approved non-steroidal anti-inflammation drug
(NSAID), sulindac [35], is demonstrated by … Seigle-Murandi F, Simeon de Buochberg M (1994)
Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone …

… J. Med. Chem., 27 (1984), pp. 990-994. [6] DA Boothman, S. Greer, AB PardeePotentiation of
halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone
(3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione), a novel DNA repair inhibitor …