Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation

B Luginbühl, Z Kanyo, RM Jones, RJ Fletterick… - Journal of molecular …, 2006 - Elsevier
Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative prion disease
affecting cattle that is transmissible to humans, manifesting as a variant of Creutzfeldt-Jakob
disease (vCJD) likely following the consumption of meat contaminated with BSE prions …