BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions

F Diehl, M Li, Y He, KW Kinzler, B Vogelstein… - Nature …, 2006 - nature.com
The most important biotechnological advances made in the 20th century involved methods
that converted single DNA molecules into populations of identical DNA molecules. The first
wave of techniques used cells (cloning) 1 and the second used PCR2. Cloning was …