Probing a protein–protein interaction by in vitro evolution
G Thom, AC Cockroft, AG Buchanan… - Proceedings of the …, 2006 - National Acad Sciences
In this study, we used in vitro protein evolution with ribosome and phage display to optimize
the affinity of a human IL-13-neutralizing antibody, a therapeutic candidate for the treatment
of asthma,> 150-fold to 81 pM by using affinity-driven stringency selections. Simultaneously …
the affinity of a human IL-13-neutralizing antibody, a therapeutic candidate for the treatment
of asthma,> 150-fold to 81 pM by using affinity-driven stringency selections. Simultaneously …
