Abstract In 1981, R. Edgar Hope-Simpson proposed that a 'seasonal stimulus' intimately
associated with solar radiation explained the remarkable seasonality of epidemic influenza.
Solar radiation triggers robust seasonal vitamin D production in the skin; vitamin D  …

Background: To our knowledge, no rigorously designed clinical trials have evaluated the
relation between vitamin D and physician-diagnosed seasonal influenza. Objective: We
investigated the effect of vitamin D supplements on the incidence of seasonal influenza A in …

… Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E. Epidemic influenza
and vitamin D. Epidemiol Infect 2006; 134: 1129–1140 … 14 Aloia JF, Li-Ng M. Re: epidemic
influenza and vitamin D. Epidemiol Infect 2007; 135: 1095–1096. author reply 1097-1098 …

AbstractObjective:. The objective was to provide guidelines to clinicians for the evaluation,
treatment, and prevention of vitamin D deficiency with an emphasi.

… Cannell JJ, Vieth R, Umhau JC, et al. Epi- demic influenza and vitamin D. Epidemiol Infect.
2006;134(6):1129–1140 13 … 2011;127(6). Available at: www. pediatrics.org/cgi/content/full/127/
6/e1513 17. Aloia JF, Li-Ng M. Re: epidemic influenza and vitamin D. Epidemiol Infect …

… Medical Progress. Vitamin D Deficiency. Michael F. Holick, MD, Ph.D … In this review I consider
the nature of vitamin D deficiency, discuss its role in skeletal and nonskeletal health, and suggest
strategies for its prevention and treatment. Sources and Metabolism of Vitamin D …

… Lancet 2000;355 (9204) 618- 621PubMedGoogle ScholarCrossref. 11. Cannell JJVieth RUmhau
JC et al. Epidemic influenza and vitamin D. Epidemiol Infect 2006;134 (6) 1129-
1140PubMedGoogle ScholarCrossref. 12. Laaksi IRuohola JPTuohimaa P et al …

… have considered a daily Vitamin D dose of only 400 IU, which confers little health benefit.
Nonetheless, a few studies have confirmed some of the findings from observational studies, such
as for fractures [43], all-cancer incidence [44], and type A influenza [45], however, this was …

… were based in part on epidemiological data linking seasonal variations in vitamin D status with
the seasonality of infections such as influenza, 72 as well as randomized clinical studies
demonstrating protective effects of vitamin D supplementation against colds and influenza …

… D induces the gene encoding the antimicrobial peptide LL-37 [3]. This peptide has potent
bactericidal capacity against a number of important bacteria and viruses, including M. tuberculosis
and influenza-virus [4], [5]. In fact, human macrophages rely upon the vitamin D/LL-37 …