... Consistent with the fact that chronic lith- ium decreases the turnover of AA within brain phos-
pholipids by up to 80% (9) and attenuates brain PLA2 activity (22), the lack of effect of lithium
on DHA re- cycling and turnover suggests that a therapeutic effect of lithium is to attenuate ...

... Treatment for 21 days with either lithium or rubidium did not cause significant alterations in
[3H]DHA binding in the rat brain cerebral cortex, cerebellum, or hypothalamus (Table 3). Similarly,
no effect was observed on [3H]QNB binding to muscarinic cholinergic receptors in ...

... and measuring membrane 15-LOX protein and activity might be helpful. Whether
15-LOX or other yet-to-be identified enzymes or pathways (16) are involved in
17-OH-DHA formation following lithium remains to be elucidated. ...

... 12 The stereochemistry of aldol products 14 and 15 was also determined by their conversion
to 5,6-dideoxy-2-erythro-hexulose and erythro-pentulose, respectively. Table 1. Aldol
reactions of the lithium enolates of DHA derivatives with aldehydes. ...

... ns, not significantly different Table 3. Effect of pretreatment with 6-hydroxydopamine
(6-OH- DA), desipramine (DES), and lithium (Li) on 3H-dihydroalprenolol (~H-DHA) and
3H-prazosin (3H-PRAZ) binding to membranes of rat cerebral cortex ...

... [3H]-DHA binding. The effect of 5 weeks of treatment with lithium on pineal [3H]DHA binding
is presented in figure 2. The data represent averages of five separate experiments each
consisting of five pooled animals. Both saturation curves and ...

... action. There was no effect of lithium on [3H]DHA binding or on its dis- placement
by I-isoproterenol. Lithium also interferes with the stimulation of adenylyl cyclase
by other hor- mones (in other tissues) (FORN, 1976). suggesting ...

... Effects of chronic lithium treatment on [3H] DHA binding Dietary administration of
lithium carbonate for 21 days significantly decreased the density of [3H]DHA binding
sites in cerebral cortical membranes (Fig. 1). B,,,ax values ...

... Rapoport, RC Murphy and SE Farias, unpublished observations). Thus, there may
be a synergy between aspirin and lithium in forming anti-inflammatory brain DHA
metabolites. In this regard, neuroinflammation is reported in BD ...