Current and experimental treatments of Parkinson disease: A guide for neuroscientists

W Oertel, JB Schulz - Journal of neurochemistry, 2016 - Wiley Online Library
… Over a period of more than 50 years, the symptomatic treatment of the motor symptoms of
Parkinson disease (PD) has been optimized using pharmacotherapy, deep brain stimulation, …

Regulation of protein kinase C by the anti‐Parkinson drug, MAOB inhibitor, rasagiline and its derivatives, in vivo

O Bar‐Am, M Yogev‐Falach, T Amit… - Journal of …, 2004 - Wiley Online Library
… We have recently shown that the anti-Parkinson-propargyl-containing monoamine oxidase
B (MAO-B) inhibitor drug, rasagiline [N-propargyl-(1R)-aminoindan], and its cholinesterase …

Symptom relief in Parkinson disease by safinamide: biochemical and clinical evidence of efficacy beyond MAO-B inhibition

F Stocchi, L Vacca, P Grassini, MF De Pandis… - Neurology, 2006 - AAN Enterprises
… as evaluated by the Unified Parkinson Disease Rating Scale (… Because MAO-B was fully
inhibited (95%) at all doses tested, we … MAO-B inhibitor, 6 providing complete platelet MAO-B

[HTML][HTML] Neuroprotection of MAO-B inhibitor and dopamine agonist in Parkinson disease

P Kong, B Zhang, P Lei, X Kong, S Zhang… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
… the MAO-B inhibitor and DA agonist drugs have neuroprotective activity were selected to
explore their neuroprotective effect on Parkinson … agents for the treatment of Parkinson disease. …

[HTML][HTML] G/A polymorphism in intronic sequence affects the processing of MAO-B gene in patients with Parkinson disease

E Jakubauskiene, V Janaviciute, I Peciuliene… - FEBS letters, 2012 - Elsevier
… levels of MAO-B mRNA and enzymatic activity have been reported in platelets from patients
with Parkinson’… The increased MAO-B protein levels might serve as a surrogate marker for – …

Gene‐Gene Interaction Between FGF20 and MAOB in Parkinson Disease

X Gao, WK Scott, G Wang, G Mayhew… - Annals of human …, 2008 - Wiley Online Library
… oxidase B (MAOB) genes are associated with Parkinson Disease … MAOB genes for evidence
of interaction contributing to PD risk. Fourteen polymorphisms (eight for FGF20, six for MAOB

Polymorphism in environment responsive genes and association with Parkinson disease

M Singh, AJ Khan, PP Shah, R Shukla… - Molecular and cellular …, 2008 - Springer
… –detoxication and dopaminergic pathways and susceptibility to Parkinson’s disease (PD). …
Significant association was observed for monoamine oxidase-B(MAO-B) variant allele G …

Family‐based case–control study of MAOA and MAOB polymorphisms in Parkinson disease

SJ Kang, WK Scott, YJ Li, MA Hauser… - … : official journal of the …, 2006 - Wiley Online Library
… and MAOB located on the X chromosome, have been considered as possible factors in the
pathogenesis of Parkinson disease (PD). Previous association studies of PD and MAO genes …

[PDF][PDF] Managing the patient with newly diagnosed Parkinson disease

C Singer - Cleveland Clinic journal of medicine, 2012 - scholar.archive.org
… ) decline was slower when STN DBS was administered earlier in the course of Parkinson
Parkinson Study Group. A controlled trial of rotigotine monotherapy in early Parkinson’s …

Treatment options in the modern management of Parkinson disease

AHV Schapira - Archives of Neurology, 2007 - jamanetwork.com
… Decision pathway for the treatment of advancing and complex Parkinson disease. MAO-BI
indicates monoamine oxidase B inhibitor; COMT-I, catechol-O-methyltransferase inhibitor. …