The pineal hormone melatonin is potentially useful in the treatment of disorders, especially
sleep disorders, associated with circadian rhythm disturbance. We have examined its effects
on sleep, mood, and behaviour in a double-blind, placebo-controlled study of a small ...

M-II, M-III, and M-IV, were measured in serum. Metabolite MII, which has shown weak
ramelteon-like activity in vitro, was the major metabolite in serum. Digit Symbol Substitution
Test and visual analog scale alertness scores were similar across all dose groups and did ...

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Abstract: A comprehensive investigation was carried out to determine the changes that
occurred in water-stressed cucumber (Cucumis sativus L.) in response to melatonin
treatment. We examined the potential roles of melatonin during seed germination and root ...

... Sleep maintenance and initiation were further improved following the 2-month
1-mg sustained-release melatonin treatment, indicating that tolerance had not
developed. After cessation of treatment, sleep quality deteriorated. ...

Possible reversal by melatonin of morphine-induced tolerance and dependence was
studied in mice. A 10-day repeated injection regimen was followed to induce morphine
tolerance and dependence. Co-administration of melatonin (1–10 mg/kg, ip) with ...

BACKGROUND: Melatonin has anxiolytic and potential analgesic effects. We assessed the
efficacy of melatonin premedication in reducing tourniquet-related pain and improving
analgesia in patients receiving IV regional anesthesia (IVRA). METHODS: Forty patients ...

In our earlier study, we reported the ability of melatonin to reverse the development of
morphine tolerance and dependence in mice. In the present study, we attempted to analyse
the possible involvement of putative melatonin receptors, central and peripheral ...

A 43 year old woman had suffered from insomnia for the past 11 years and was being
treated with benzodiazepines. All attempts to stop benzodiazepine treatment resulted in
withdrawal symptoms and a renewal of the insomnia. Treatment with 1 mg of controlled ...

Abstract This study examined whether the reported hypothermic effect of melatonin ingestion
increased tolerance to exercise at 40 C, for trials conducted either in the morning or
afternoon, while subjects were wearing protective clothing. Nine men performed four ...