… genes are induced by ionizing radiation (24). The N-terminal part of mammalian … radioactive
labelling corresponding to poly(ADP-ribosyl)ated hXRCC1. Thus, as … cells, such as ATM (36),
p53 (37), T:G mismatch-specific thymidine-DNA glycosylase Page 27 …

… Following whole body γ-irradiation (8 Gy) mutant mice died rapidly from acute radiation toxicity
to the small intestine … Altogether these results demonstrate that PARP is a survival factor playing
an essential and positive role during DNA damage recovery …

… selective enough nor potent enough by current standards, demonstrated enhanced radiation
sensitivity when poly … Each day, normal cells repair thousands of DNA lesions that result from
various … and PARP2 promote the repair of these lesions by base excision repair (BER) 33 …

… Article. Functional interaction between PARP‐1 and PARP‐2 in chromosome stability
and embryonic development in mouse. Josiane Ménissier de Murcia, Michelle Ricoul,
Laurence Tartier, Claude Niedergang, Aline Huber, Françoise …

… Upon γ-irradiation, the activation of the Atm kinase by autophosphorylation induced-
monomerization … ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA
repair in association … Ionising radiation induces the expression of PARP-1 and PARP-2 genes …

… PARP-1 +/+ cells (a), but localized to the nucleus 6 h after irradiation at 0.5 … upregulated, activity
of PARP-2. The effect of PARP status on radiation sensitivity appears … suggest that PARP inhibitors
may be of therapeutic value in combination with radiotherapy regimens comprising …

… In response to DNA-strand breaks introduced either directly by ionizing radiation or indirectly
following enzymatic … The radioactive spots on the TLC were scraped from the thin layer and 32
P label … 4 mm MgCl 2 , 200 μm dithiothreitol, 200 ng of calf thymus DNA previously treated …

… also have been shown to direct the recruitment of various proteins to sites of DNA damage … The
binding of PARP1 to DNA breaks stimulates its enzymatic activity and leads to the rapid … This
assembly leads to the recruitment of X-ray repair cross-complementing group 1 (XRCC1 …

… Ionising radiation induces various types of DNA dam- age (Hutchinson 1985) that need to be …
of DNA damage and the efficiency of repair, the cellular response to irradiation can lead to … of
PARP-1 [Poly(ADP-Ribose) Polymerase-1] in cell recovery from DNA damage induced by …