... Although clearly a good deal of additional work will be needed to establish the range
of age effects that are or are not modulated by rapamycin, it now seems safe to
conclude that TOR inhibition does indeed slow aging in mice. ...

Page 1. The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity
and Lifetime Energy Intake1 RICHARD WEINDRUCH, ROY L. WALFORD, SUZANNE FLIGIEL2
ANDDONALD GUTHRIE* ... Page 3. DIETARY RESTRICTION AND AGING IN MICE 643 ...

... Reduced thyroid hormone synthesis also is characteristic of pituitary mutants with retarded
aging (Fig. 1C). Because of their low thyroid function, dwarf mice exhibit traits hypothesized
to slow senescence, including hypothermia and delayed maturation. ...

... CR. Further, ST-CR substantially shifted the “normo-aging” genomic profile of old
control mice toward the “slow-aging” profile associated with LT-CR. Therefore, many
of the genomic effects of CR are established rapidly. Thus ...

... steroid-responsive tissues. We observed that different tissues age in a coordinated
fashion in individual mice, such that certain mice exhibit rapid aging, whereas others
exhibit slow aging for multiple tissues. Finally, we compared ...

... In yeast, an extra copy of SIR2 does slow aging and increase life span. It should
be possible to carry out similar tests in experimental animals, such as Caenorhabditis
elegans and mice. In humans the task is more formidable. ...

... In contrast to the situation in mice [56], the effect of CR in rats is not limited to suppression
of increases in ROS production with age. ... Therefore, this decrease could be a basic mechanism
responsible for the slow aging rate of calorie-restricted animals. ...

... such as cysteine, which affords some radiation protection, would be expected to slow down the ...
Some of the implications of this theory both as it pertains to aging and to cancer ... Groups of mice
of the AKR and C3H strains, which spontaneously develop lymphatic leukemia and ...

Abstract Work in yeast has shown that longevity extension induced by nutrient deprivation,
altered ribosomal function, or diminished target of rapamycin action requires the activity of
GCN4. We hypothesized that increased activity of ATF4, the mammalian equivalent of ...