... a new role for pediatricians to promote the development and implementation of science-based
strategies to reduce toxic stress in early childhood as a ... of Pediatrics reviewed 58 years of
published studies and characterized racial and ethnic disparities in children's health to be ...

... We then examined glucocorticoid feedback sensitivity in the high– and low–LG-ABN offspring
by administering a bolus injection of ... high–LG-ABN mothers, like the handled animals, show
increased sensitivity to the inhibitory effects of glucocorticoids on stress-induced HPA ...

... Full Text via CrossRef. Kiser, et al, 1991; LJ Kiser, J Heston, PA Millsap, DB Pruitt; Physical and
sexual abuse in childhood: Relationship with posttraumatic stress disorder. ... Glucocorticoids
accelerate ATP loss following metabolic insults in cultured hippocampal neurons. ...

Review from JAMA — Neuroscience, Molecular Biology, and the Childhood Roots of Health
Disparities — Building a New Framework for Health Promotion and Disease Prevention.

... In this report, we begin by outlining the core concepts of biological adaptation to stressful
circumstances, including ... In making the case for preventing risk factors for toxic stress, pediatricians
can help build bridges in the public discourse between childhood experiences and ...

... Although this study does not rule out the possibility of an added toxic environmental effect, they ...
16,17 Elevated cortisol levels suggest that high levels of stress lead to activation of the HPA axis
and cortisol production and that this leads to hippocampal toxicity, which results ...

... Please enable JavaScript to use all the features on this page. Neuroscience & Biobehavioral
Reviews. Volume 27, Issues 1–2, January–March 2003, Pages 33–44. Brain Development, Sex
Differences and Stress: Implications for Psychopathology. Cover image.

... Sustained exposure to glucocorticoids, the adrenocortical stress hormones, is toxic to neurons,
and such toxicity appears to ... Pharmacological interventions that diminish the adrenocortical stress
response may improve neurological outcome from stroke or cardiac arrest. ...

... to resist insults, increasing the rate at which they are damaged by other toxic challenges or ... many
cities are chronically exposed, at background levels, to a range of common toxins that are ... Glover,
V. Maternal stress or anxiety in pregnancy and emotional development of the child ...

... measured with MRI (Bremner, Krystal, Southwick, & Charney, a hormonal system required for
survival can actually be toxic to the ... binding to- gether different aspects of a memory at the If
traumatized children are suffering from stress-induced hippocampal toxicity with as ...