The emerging role of unmetabolized folic acid in human diseases: myth or reality?

R Obeid, W Herrmann - Current drug metabolism, 2012 - ingentaconnect.com
… of breakfast cereals or staple foods with folic acid (FA), which is the … The presence of detectable
amounts of unmetabolised FA in … between FA intake and unmetabolised FA in serum and …

Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements

P Kelly, J McPartlin, M Goggins… - The American journal …, 1997 - academic.oup.com
… intake of 266 jtg folic acid per meal at which … red cell folate and serum folate and folic
acid concentrations. … folic acid as fortified RTEC and bread at total daily intakes of 90, 400, …

Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women

AM Troen, B Mitchell, B Sorensen… - The Journal of …, 2006 - academic.oup.com
… of unmetabolized FA in plasma as a biochemical marker of excess FA. Unmetabolized folic
acid … We found an inverse relation between the presence of unmetabolized FA in plasma and …

High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood

L Plumptre, SP Masih, A Ly, S Aufreiter… - … American journal of …, 2015 - academic.oup.com
… maternal and cord blood concentrations of folate and unmetabolized folic acid (UMFA) in a
cohort … of folate and folic acid and fetal genetic variants in folate metabolism on folate status. …

[HTML][HTML] Circulating unmetabolized folic acid: relationship to folate status and effect of supplementation

C Tam, D O'Connor, G Koren - Obstetrics and gynecology international, 2010 - hindawi.com
… that exposure to unmetabolized folic acid, which results from folic acid intakes that … folic
acid status of women of reproductive age in relation to dietary intake and the effect of folic acid

Unmetabolized folic acid is detected in nearly all serum samples from US children, adolescents, and adults

CM Pfeiffer, MR Sternberg, Z Fazili… - The Journal of …, 2015 - academic.oup.com
… has limited ability to reduce and methylate folic acid (6). … of folic acid (100 μg) within a day
have been shown to result in the appearance of folic acid in serum, ie, unmetabolized folic acid

Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors

MS Morris, PF Jacques, IH Rosenberg… - The American journal …, 2010 - academic.oup.com
folate was measured, the role that unmetabolized folic acid played in the results was unclear.
In the present investigation, we assayed 5MeTHF and unmetabolized folic acid … total folate

[HTML][HTML] Folic acid fortification and public health: report on threshold doses above which unmetabolised folic acid appear in serum

MR Sweeney, J McPartlin… - BMC public …, 2007 - bmcpublichealth.biomedcentral.com
… The accumulation of folic acid after consumption of fortified bread repeatedly over only one
8… we examined unmetabolised folic acid appearance after consumption of folic acid for a …

Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood

R Obeid, M Kasoha, SH Kirsch, W Munz… - … American journal of …, 2010 - academic.oup.com
… lower proportion of total folate in cord serum than in maternal serum. Conclusions: We
detected unmetabolized folic acid in more than one-half of cord blood samples. Folic acid (400 μg/…

Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults

R Obeid, SH Kirsch, M Kasoha, R Eckert, W Herrmann - Metabolism, 2011 - Elsevier
… wide variations in folate forms at baseline, but these were reduced after FA treatment. Folic
acid given to … of tHcy, but caused a substantial increase in unmetabolized FA in the plasma. …