Fundamentals of freeze-drying
SL Nail, S Jiang, S Chongprasert, SA Knopp - … and manufacture of protein …, 2002 - Springer
SL Nail, S Jiang, S Chongprasert, SA Knopp
Development and manufacture of protein pharmaceuticals, 2002•SpringerThe development of freeze-dried injectable pharmaceutical products has traditionally been a
process of trial and error, both with respect to the composition of the formulation and the
process conditions used during freeze-drying. Although this approach ultimately may result
in an acceptable product, it is a time-consuming and labor-intensive process, and is unlikely
to result in the highest quality product attainable or in a freeze-dry process which is
optimized.
process of trial and error, both with respect to the composition of the formulation and the
process conditions used during freeze-drying. Although this approach ultimately may result
in an acceptable product, it is a time-consuming and labor-intensive process, and is unlikely
to result in the highest quality product attainable or in a freeze-dry process which is
optimized.
Abstract
The development of freeze-dried injectable pharmaceutical products has traditionally been a process of trial and error, both with respect to the composition of the formulation and the process conditions used during freeze-drying. Although this approach ultimately may result in an acceptable product, it is a time-consuming and labor-intensive process, and is unlikely to result in the highest quality product attainable or in a freeze-dry process which is optimized.
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