Monitor lyophilization with mass spectrometer gas analysis
JP Connelly, JV Welch - PDA Journal of Pharmaceutical Science …, 1993 - journal.pda.org
JP Connelly, JV Welch
PDA Journal of Pharmaceutical Science and Technology, 1993•journal.pda.orgThis paper presents a brief review of the basic issues of lyophilization and the fundamentals
of quadrupole mass spectrometry. The emphasis of the paper is on the application of a
quadrupole mass spectrometer as a process monitor. The details of sampling and data
collection are discussed. Data taken while monitoring lyophilization is presented in
conjunction with cycle optimization, end point detection and contaminant detection.
of quadrupole mass spectrometry. The emphasis of the paper is on the application of a
quadrupole mass spectrometer as a process monitor. The details of sampling and data
collection are discussed. Data taken while monitoring lyophilization is presented in
conjunction with cycle optimization, end point detection and contaminant detection.
This paper presents a brief review of the basic issues of lyophilization and the fundamentals of quadrupole mass spectrometry. The emphasis of the paper is on the application of a quadrupole mass spectrometer as a process monitor. The details of sampling and data collection are discussed. Data taken while monitoring lyophilization is presented in conjunction with cycle optimization, end point detection and contaminant detection.
journal.pda.org