Anaesthesiol Intensive Ther 2021; 53, 4: 358–359 group had previously been exposed to other strains of influenza virus, and the similarity between strains led to the production of cross-reactive broadly neutralizing antibodies [4]. On the other hand, younger individuals who had not been exposed to these influenza viruses were susceptible to infection with the novel H1N1 strain. Thus, if SARS-CoV-2 were completely novel, it would be unlikely that susceptibility to infection would vary by age, and there would be few asymptomatic cases. In fact, compared to younger/middle-aged adults, susceptibility to infection for children younger than 10 years is estimated to be significantly lower, while estimated susceptibility to infection in adults older than 60 years is higher [5]. Healthy immune systems with prior exposure to other coronaviruses can generate broadly neutralizing antibodies, which can reduce the severity of COVID-19 [3]. Therefore, it is important to avoid suppressing immune responses in infected individuals. This report emphasizes five key recommendations for the management of COVID-19 that have gained limited attention.

1. Limit the use of antipyretic analgesics in lowering the core body temperature: The ideal body temperature ranges between 36.8 C and 37.1 C. When the body temperature increases, immune function improves. A body temperature of 40 C deactivates common viruses within a short time [6]; therefore, limited use of antipyretic analgesics (eg, nonsteroidal anti-inflammatory drugs and acetaminophen) is recommended [7]. Instead, a high fever can be managed