Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF)
A Burger-Kentischer, H Göbel, R Kleemann… - Atherosclerosis, 2006 - Elsevier
Atherosclerosis is an inflammatory response of the arterial wall to “injury”, which is
prominently driven by cytokines. The inflammatory mediator macrophage migration
inhibitory factor (MIF) is a unique cytokine that was recently associated with atherogenesis.
Here, we have investigated whether MIF has a role in spontaneous atherosclerosis by
studying apolipoprotein E-deficient (ApoE−/−) mice treated with neutralizing anti-MIF
monoclonal antibody and comparison with isotype IgG-treated controls. After 14 weeks, the …
prominently driven by cytokines. The inflammatory mediator macrophage migration
inhibitory factor (MIF) is a unique cytokine that was recently associated with atherogenesis.
Here, we have investigated whether MIF has a role in spontaneous atherosclerosis by
studying apolipoprotein E-deficient (ApoE−/−) mice treated with neutralizing anti-MIF
monoclonal antibody and comparison with isotype IgG-treated controls. After 14 weeks, the …
