This is the 25th anniversary of the discovery of extended longevity mutants in
Caenorhabditis elegans. About one hundred papers describing results from studies on C.
elegans in aging research appeared this year. Many themes were pursued including dietary
restriction, daf-9 action, the role of proteolysis and autophagy, and the continued search for
more Age mutants. I use the word “modulate” not “regulate” so as to be consistent with the
evolutionary theory of aging, which is also consistent with the empirical findings of all …