Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans
K Houthoofd, BP Braeckman, TE Johnson… - Experimental …, 2003 - Elsevier
Dietary restriction (DR) increases life span in a wide variety of animals. In Caenorhabditis
elegans both reduced bacterial concentration (BDR) and culture on non-bacterial, semi-
defined, axenic food sources (ADR) increased longevity. An Ins/IGF-1-like (IIF) signalling
pathway has been shown to specify life span in C. elegans and it has been suggested that
this IIF signalling pathway mediates life extension via DR. We show that both ADR and BDR
act independently with mutations in the IIF pathway to increase longevity, stress resistance …
elegans both reduced bacterial concentration (BDR) and culture on non-bacterial, semi-
defined, axenic food sources (ADR) increased longevity. An Ins/IGF-1-like (IIF) signalling
pathway has been shown to specify life span in C. elegans and it has been suggested that
this IIF signalling pathway mediates life extension via DR. We show that both ADR and BDR
act independently with mutations in the IIF pathway to increase longevity, stress resistance …