Increased release of tumour cells by collagenase at acid pH: a possible mechanism for metastasis
GA Turner - Experientia, 1979 - Springer
GA Turner
Experientia, 1979•SpringerIncreased release of tumour cells by collagenase at acid pH: A possible mechanism for
metastasis Page 1 Experientia 35 (1979), Birkhauser Verlag, Basel (Schweiz) activities of the
offspring 9. Similar findings have been reported by others 4. X-irradiation of pregnant mice on
gestational days 11, 12 and 13, with 1.05 Gy each time, also caused marked and significant
changes in postnatal brain weights, protein content, acetylcholinesterase and Na, KATPase
activities of all offspring (table). Increased mortality, however, was observed only with females …
metastasis Page 1 Experientia 35 (1979), Birkhauser Verlag, Basel (Schweiz) activities of the
offspring 9. Similar findings have been reported by others 4. X-irradiation of pregnant mice on
gestational days 11, 12 and 13, with 1.05 Gy each time, also caused marked and significant
changes in postnatal brain weights, protein content, acetylcholinesterase and Na, KATPase
activities of all offspring (table). Increased mortality, however, was observed only with females …
Summary
The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.
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