Oxidative and reductive mechanisms are important in Wilson's disease. In this study, we
sought to evaluate tissue levels of glutathione and cysteine, an important detoxification
system, and of malondialdehyde, a marker of lipoperoxidation, in patients with Wilson's
disease receiving penicillamine or zinc treatment, in comparison with patients with chronic
liver disease of different origin. Concentrations of cysteine, reduced/oxidized glutathione,
malondialdehyde, zinc, and copper were determined (with the use of high-pressure liquid …