Interleukin-6 and the development of social disruption-induced glucocorticoid resistance
JL Stark, R Avitsur, J Hunzeker, DA Padgett… - Journal of …, 2002 - Elsevier
Following social disruption (SDR) stress in male mice, corticosterone resistance of
splenocytes was accompanied by enhanced LPS-stimulated interleukin (IL)-6 secretion. The
present study examined the role of IL-6 in the development of corticosterone resistance.
Addition of IL-6 to control splenocyte cultures did not induce corticosterone resistance. SDR
also elevated IL-6 in plasma and liver, but not in spleen. IL-6 deficient mice that were
exposed to SDR developed glucocorticoid resistance despite the absence of systemic IL-6 …
splenocytes was accompanied by enhanced LPS-stimulated interleukin (IL)-6 secretion. The
present study examined the role of IL-6 in the development of corticosterone resistance.
Addition of IL-6 to control splenocyte cultures did not induce corticosterone resistance. SDR
also elevated IL-6 in plasma and liver, but not in spleen. IL-6 deficient mice that were
exposed to SDR developed glucocorticoid resistance despite the absence of systemic IL-6 …
