Oxidative injury and hepatocyte apoptosis in total parenteral nutrition–associated liver dysfunction

W Cai, J Wu, L Hong, Y Xu, Q Tang, C Shi - Journal of pediatric surgery, 2006 - Elsevier
PURPOSE: The aim of this study was to investigate the impact of oxidative injury and
apoptosis on total parenteral nutrition (TPN)–associated hepatic dysfunction. METHODS:
Fifty-nine New Zealand rabbits (6-8 days old) were divided into 4 groups: 12 in the control
group (maternal fed), 15 in the PN-3 group (TPN for 3 days), 14 in the PN-7 group (TPN for 7
days), and 18 in the PN-10 group (TPN for 10 days). At the end of the experiment, blood
biochemistry analysis and histologic examination of the liver were performed; the …