Hypocalcemia complicating deferoxamine therapy in an infant with parenteral nutrition-associated aluminum overload: evidence for a role of aluminum in the bone …
GL Klein, WR Snodgrass, MP Griffin… - Journal of pediatric …, 1989 - europepmc.org
Aluminum (Al) contaminates total parenteral nutrition (TPN) solutions given to infants, and
high levels of Al have been demonstrated in their bone, serum, and urine. However, it is
uncertain whether Al at current levels of contamination of TPN solutions is harmful to bone.
We report an 8-month-old infant who developed osteopenic bone disease while receiving
TPN, which did not respond to large amounts of calcium, phosphate, and vitamin D2. Serum
and urine Al levels were greatly elevated and fell after a short course of deferoxamine …
high levels of Al have been demonstrated in their bone, serum, and urine. However, it is
uncertain whether Al at current levels of contamination of TPN solutions is harmful to bone.
We report an 8-month-old infant who developed osteopenic bone disease while receiving
TPN, which did not respond to large amounts of calcium, phosphate, and vitamin D2. Serum
and urine Al levels were greatly elevated and fell after a short course of deferoxamine …
