Caloric restriction (CR) is currently the only therapeutic intervention known to attenuate
aging in mammals, but the underlying mechanisms of this phenomenon are still poorly
understood. To get more insight into these mechanisms, we took advantage of the αMUPA
transgenic mice that previously were reported to spontaneously eat less and live longer
compared with their wild-type control mice. Currently, two transgenic lines that eat less are
available, thus implicating the transgenic enzyme, ie the urokinase-type plasminogen …