[HTML][HTML] Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
M Imai, T Watanabe, M Hatta, SC Das, M Ozawa… - Nature, 2012 - nature.com
Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans, but currently
do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known
host-range determinant as it mediates virus binding to host-specific cellular receptors 1, 2, 3.
Here we assess the molecular changes in HA that would allow a virus possessing subtype
H5 HA to be transmissible among mammals. We identified a reassortant H5 HA/H1N1 virus—
comprising H5 HA (from an H5N1 virus) with four mutations and the remaining seven gene …
do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known
host-range determinant as it mediates virus binding to host-specific cellular receptors 1, 2, 3.
Here we assess the molecular changes in HA that would allow a virus possessing subtype
H5 HA to be transmissible among mammals. We identified a reassortant H5 HA/H1N1 virus—
comprising H5 HA (from an H5N1 virus) with four mutations and the remaining seven gene …
