Recent research utilizing a computable general equilibrium (CGE) model of the U.S. economy called United States Applied General Equilibrium–International Trade Commission (USAGE-ITC) to evaluate the national effects of maritime infrastructure investment in Texas is described. After a brief description of the model, which was developed for the U.S. International Trade Commission, the present application to an analysis of federal investments in channel deepening along Texas’ shallow draft waterways is discussed and future transportation applications are suggested. The estimates of national economic benefits from the analyzed investments are significant and illustrate the potential contribution of CGE models to the evaluation of infrastructure investment programs of federal agencies, such as the U.S. Army Corps of Engineers. The objective of this paper is to increase awareness among transportation researchers and planners of the role for CGE models in evaluations of transportation infrastructure projects and programs.