A randomized controlled trial of intranasal ketamine in major depressive disorder
KAB Lapidus, CF Levitch, AM Perez, JW Brallier… - Biological …, 2014 - Elsevier
Background The N-methyl-D-aspartate glutamate receptor antagonist ketamine, delivered
via an intravenous route, has shown rapid antidepressant effects in patients with treatment-
resistant depression. The current study was designed to test the safety, tolerability, and
efficacy of intranasal ketamine in patients with depression who had failed at least one prior
antidepressant trial. Methods In a randomized, double-blind, crossover study, 20 patients
with major depression were randomly assigned, and 18 completed 2 treatment days with …
via an intravenous route, has shown rapid antidepressant effects in patients with treatment-
resistant depression. The current study was designed to test the safety, tolerability, and
efficacy of intranasal ketamine in patients with depression who had failed at least one prior
antidepressant trial. Methods In a randomized, double-blind, crossover study, 20 patients
with major depression were randomly assigned, and 18 completed 2 treatment days with …
