Anticonvulsant effects of melatonin in amygdala-kindled rats
M Mevissen, U Ebert - Neuroscience letters, 1998 - Elsevier
Abstract Different doses of melatonin (50–100 mg/kg ip) were tested for their ability to
suppress complex partial seizures in the amygdala kindling model of the rat. Thirty minutes
after injection of 75 or 100 mg/kg melatonin, the current threshold necessary to elicit
epileptic afterdischarges (ADT) was significantly increased by about 200 or 250%,
respectively. These doses were also sufficient to suppress generalised seizures at threshold
current. All doses of melatonin decreased body temperature by more than 0.5° C, but …
suppress complex partial seizures in the amygdala kindling model of the rat. Thirty minutes
after injection of 75 or 100 mg/kg melatonin, the current threshold necessary to elicit
epileptic afterdischarges (ADT) was significantly increased by about 200 or 250%,
respectively. These doses were also sufficient to suppress generalised seizures at threshold
current. All doses of melatonin decreased body temperature by more than 0.5° C, but …
