The bidirectional comorbidity between epilepsy and depression is associated with severe
challenges for treatment efficacy and safety, often resulting in poor prognosis and outcome
for the patient. We showed previously that rats selectively bred for depression-like behaviors
(SwLo rats) also have increased limbic seizure susceptibility compared with their depression-
resistant counterparts (SwHi rats). In this study, we examined the therapeutic efficacy of
voluntary exercise in our animal model of epilepsy and depression comorbidity. We found …