Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression
ZV Segal, P Bieling, T Young… - Archives of general …, 2010 - jamanetwork.com
Context Mindfulness-based cognitive therapy (MBCT) is a group-based psychosocial
intervention designed to enhance self-management of prodromal symptoms associated with
depressive relapse. Objective To compare rates of relapse in depressed patients in
remission receiving MBCT against maintenance antidepressant pharmacotherapy, the
current standard of care. Design Patients who met remission criteria after 8 months of
algorithm-informed antidepressant treatment were randomized to receive maintenance …
intervention designed to enhance self-management of prodromal symptoms associated with
depressive relapse. Objective To compare rates of relapse in depressed patients in
remission receiving MBCT against maintenance antidepressant pharmacotherapy, the
current standard of care. Design Patients who met remission criteria after 8 months of
algorithm-informed antidepressant treatment were randomized to receive maintenance …
