The economic and financial feasibility of heavy-truck toll lanes was analyzed. This research expanded the line of inquiry of previous researchers by analyzing toll lanes for exclusive use by heavy trucks (i.e., large size and capacity). Implementation of such a toll system was studied relative to productivity changes, toll-lane fees, users' travel time and vehicle operating cost savings, and impact on infrastructure costs. The economic benefits were estimated using the Highway Design and Maintenance Standards Model developed by the World Bank. The analyses, complemented with sensitivity analyses of key variables, indicate that heavy-truck lanes are economically and financially viable.