Neuroanatomical localization and physiological properties of galanin suggest that the
peptide may be involved in the regulation of seizures. Indeed, administration of galanin
receptor agonists into brain areas pertinent to the initiation and propagation of epileptic
activity attenuated seizure responses under conditions of animal models of epilepsy;
pharmacological blocking of galanin receptors exerted proconvulsant effects. Functional
deletion of both galanin and galanin type 1 receptor genes produced transgenic mice with …