Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder
Importance Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically
overlaps with major depressive disorder (MDD) and is therefore an important phenotype for
psychiatric genetics. The Genetics of Personality Consortium has created a resource for
genome-wide association analyses of personality traits in more than 63 000 participants
(including MDD cases). Objectives To identify genetic variants associated with neuroticism
by performing a meta-analysis of genome-wide association results based on 1000 Genomes …
overlaps with major depressive disorder (MDD) and is therefore an important phenotype for
psychiatric genetics. The Genetics of Personality Consortium has created a resource for
genome-wide association analyses of personality traits in more than 63 000 participants
(including MDD cases). Objectives To identify genetic variants associated with neuroticism
by performing a meta-analysis of genome-wide association results based on 1000 Genomes …
