Background: Brain volume decreases with normal aging. We sought to determine whether,
in addition to age, individual differences in stress reactivity (ie, neuroticism) would also
predict reductions in brain volume. Methods: Brain volume ratios were calculated for a
sample of 86 healthy volunteers, based on segmented brain volumes taken from T1-
weighted magnetic resonance imaging and corrected for intracranial volume. Standardized
self-reported measures of dispositional neuroticism were concurrently obtained by …