European passenger rail systems are massively interconnected and operate with very high frequency. The effects of single-component failures on these types of systems can significantly affect technical and operational reliability. Today advanced diagnostic tools with broad functionalities are being added to systems and system components. These tools control the operation of, support the maintenance of, and monitor the highly sophisticated and interconnected components. A set of diagnostic event data from a passenger train exterior door system was used to predict the occurrence of events that might evolve into operational disruptions that affect train operation and therefore railway reliability. This approach used a neural network algorithm with dynamic temporal behavior (the echo state network) in combination with principal component analysis. The proposed approach exhibited a prediction accuracy of up to 99%.