Quantification of lean bodyweight
Background: Lean bodyweight (LBW) has been recommended for scaling drug doses.
However, the current methods for predicting LBW are inconsistent at extremes of size and
could be misleading with respect to interpreting weight-based regimens. Objective: The
objective of the present study was to develop a semi-mechanistic model to predict fat-free
mass (FFM) from subject characteristics in a population that includes extremes of size. FFM
is considered to closely approximate LBW. There are several reference methods for …
However, the current methods for predicting LBW are inconsistent at extremes of size and
could be misleading with respect to interpreting weight-based regimens. Objective: The
objective of the present study was to develop a semi-mechanistic model to predict fat-free
mass (FFM) from subject characteristics in a population that includes extremes of size. FFM
is considered to closely approximate LBW. There are several reference methods for …
