[HTML][HTML] SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor
M Hoffmann, H Kleine-Weber, S Schroeder, N Krüger… - cell, 2020 - Elsevier
The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in
China and its rapid national and international spread pose a global health emergency. Cell
entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors
and on S protein priming by host cell proteases. Unravelling which cellular factors are used
by SARS-CoV-2 for entry might provide insights into viral transmission and reveal
therapeutic targets. Here, we demonstrate that SARS-CoV-2 uses the SARS-CoV receptor …
China and its rapid national and international spread pose a global health emergency. Cell
entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors
and on S protein priming by host cell proteases. Unravelling which cellular factors are used
by SARS-CoV-2 for entry might provide insights into viral transmission and reveal
therapeutic targets. Here, we demonstrate that SARS-CoV-2 uses the SARS-CoV receptor …