STAR: ultrafast universal RNA-seq aligner
A Dobin, CA Davis, F Schlesinger, J Drenkow… - …, 2013 - academic.oup.com
Motivation: Accurate alignment of high-throughput RNA-seq data is a challenging and yet
unsolved problem because of the non-contiguous transcript structure, relatively short read
lengths and constantly increasing throughput of the sequencing technologies. Currently
available RNA-seq aligners suffer from high mapping error rates, low mapping speed, read
length limitation and mapping biases. Results: To align our large (> 80 billon reads)
ENCODE Transcriptome RNA-seq dataset, we developed the Spliced Transcripts Alignment …
unsolved problem because of the non-contiguous transcript structure, relatively short read
lengths and constantly increasing throughput of the sequencing technologies. Currently
available RNA-seq aligners suffer from high mapping error rates, low mapping speed, read
length limitation and mapping biases. Results: To align our large (> 80 billon reads)
ENCODE Transcriptome RNA-seq dataset, we developed the Spliced Transcripts Alignment …