Kainate treatment in rats can result in a chronic behavioral state that is similar to human
temporal lobe epilepsy. We tested the hypothesis that, like some humans with epilepsy, rat
with kainate-induced epilepsy have more spontaneous motor seizures during inactivity (ie
little to no volitional movement, including apparent sleep) than during activity (ie apparent
volitional movement, as in walking, grooming, eating, etc.). Rats were given intraperitoneal
(ip) injections of kainate (5 mg/kg) every hour so that class III/IV/V seizures were elicited …