The schizophrenia polygenic risk score: to what does it predispose in adolescence?
KS Kendler - JAMA psychiatry, 2016 - jamanetwork.com
The initial goal of genome-wide association studies (GWASs) of psychiatric disorders was to
identify individual genetic variants that predispose to illness. Along the way, another
application of GWAS data was discovered1: the polygenic risk score (PRS). The concept is
simple. We start with all single-nucleotide polymorphisms (SNPs) assessed in a training
sample. In this issue of JAMA Psychiatry, Jones et al2 report findings using the second
Psychiatric Genomics Consortium schizophrenia GWAS as that sample. 3 These SNPs are …
identify individual genetic variants that predispose to illness. Along the way, another
application of GWAS data was discovered1: the polygenic risk score (PRS). The concept is
simple. We start with all single-nucleotide polymorphisms (SNPs) assessed in a training
sample. In this issue of JAMA Psychiatry, Jones et al2 report findings using the second
Psychiatric Genomics Consortium schizophrenia GWAS as that sample. 3 These SNPs are …
